Chemoenzymatic synthesis of acetyl (R)-(+)- and (S)-(-)-cycloserine

Article abstract of DOI:10.1016/S0957-4166(00)80156-1

The two enantiomers of acetyl cycloserine 8, the immediate precursors of the chiral forms of cycloserine 1, were prepared in enantiomeric excess higher than 98% by means of lipase-catalyzed hydrolysis of 3-benzyloxy-4-hydroxy-Δ²-isoxazoline but