Synthesis of acyclonucleoside phosphonates as antiviral agents against cytomegalovirus

DOI: 10.1080/15257779408013261

Source and publish data:

Nucleosides and Nucleotides p. 539 - 550 (1994)

Update date:2022-08-04

Topics:

Authors:

Reist Reist

Bradford III

Ruhland-Fritsch

Sturm Sturm

Zaveri Zaveri

Huffman Huffman

Sidwell Sidwell

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Article abstract of DOI:10.1080/15257779408013261

Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.

Full text of DOI:10.1080/15257779408013261

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