Synthesis of acyclonucleoside phosphonates as antiviral agents against cytomegalovirus

Article abstract of DOI:10.1080/15257779408013261

Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.

Full text of DOI:10.1080/15257779408013261

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Nucleosides and Nucleotides
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Synthesis of Acyclonucleoside
Phosphonates as Antiviral Agents Against
Cytomegalovirus
Elmer J. Reist a , Wallace W. Bradford III a , Beatrice L. Ruhland-
Fritsch a , Priscilla A. Sturm a , Nurulain T. Zaveri a , John Huffman b
& Robert W. Sidwell b
a SRI International , Menlo Park, CA, 94025
b Utah State University , Logan, UT, 84322
Published online: 23 Sep 2006.
To cite this article: Elmer J. Reist , Wallace W. Bradford III , Beatrice L. Ruhland-Fritsch , Priscilla A.
Sturm , Nurulain T. Zaveri , John Huffman & Robert W. Sidwell (1994) Synthesis of Acyclonucleoside
Phosphonates as Antiviral Agents Against Cytomegalovirus, Nucleosides and Nucleotides, 13:1-3,
539-550, DOI: 10.1080/15257779408013261
To link to this article: http://dx.doi.org/10.1080/15257779408013261
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