A versatile entry into the synthesis of α-(monofluoromethyl) amino acids : Preparation of α-(monofluoromethyl) serine and (E)-dehydro-α-(monofluoromethyl) ornithine

Article abstract of DOI:10.1016/S0040-4039(00)74090-1

A new entry to the synthesis of α-(monofluoromethyl) amino acids is described. The synthesis is based on a Strecker reaction on an α-(monofluoromethyl) ketone. As an example, α-(monofluoromethyl) serine was synthesized and used as starting material for a new synthesis of (E)-dehydro-α-(monoflouromethyl) ornithine.