Lipase Catalyzed Kinetic Resolution of Pharmaceutically Useful Chloro Alcohols in Heptane

Article abstract of DOI:10.1016/0957-4166(95)00187-T

Pharmaceutrically useful chloro alcohols, 3-chloro-1-phenyl-1-propanol (1), 1-chloro-3-(1-naphthyloxy)-2-propanol (2) and 4-chloro-1-(4-tert-butylphenyl)-1-butanol (3), are prepared in enantiomerically pure form by an efficient lipase PS catalyzed transesterification in heptane.The effect of organic solvent nature on enzyme activity was also studied.