Pyruvate Aldolases as Reagents for Stereospecific Aldol Condensation

DOI: 10.1021/jo00028a005

Source and publish data:

Journal of Organic Chemistry p. 426 - 427 (1992)

Update date:2022-08-05

Topics:

Authors:

Allen, Sarah T.

Heintzelman, Geoffrey R.

Toone, Eric J.

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Article abstract of DOI:10.1021/jo00028a005

KDPG aldolase, a representative member of the largest but as of yet unexplored group of aldolases which utilize pyruvate as the nucleophilic component in aldol condensation, accepts a number of unnatural aldehydes as electrophiles in stereospecific aldol condensation, providing access to highly and differentially functionalized α-keto acid products.

Full text of DOI:10.1021/jo00028a005

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