Synthesis of α,α,β,β-Tetrasubstituted β-Lactones from Ketones, Ethyl α-Bromoisobutyrate, and Indium or Zinc. Factors Influencing the β-Lactone Formation in the Electrochemical and the Classical Procedure of the Reformatsky Reaction

Article abstract of DOI:10.1021/jo00090a038

An efficient synthesis of α,α,β,β-tetrasubstituted β-lactones is achieved by an electrochemically supported Reformatsky reaction of aliphatic and aromatic ketones with ethyl α-bromoisobutyrate at a sacrificial indium anode.Under these conditions, in most