A practical and efficient multigram approach to daunomycinone and derivatives

DOI: 10.1016/S0040-4020(01)80160-5

Source and publish data:

Tetrahedron p. 6463 - 6472 (1993)

Update date:2022-08-03

Topics: Oxidation Characterization Derivatization Deprotection Purification Protection of Functional Groups

Authors:

De Bie, Joannes F. M.

Peperzak, Rob M.

Daenen, Marian J.

Scheeren, Hans W.

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Article abstract of DOI:10.1016/S0040-4020(01)80160-5

(+/-)-Daunomycinone and (+/-)-4-demethoxydaunomycinone have been synthesized via two successive Diels-Alder reactions from naphthazarin. Key steps for the construction of the A-ring of the anthracyclinone are the Diels-Alder reaction of the BCD fragments

Full text of DOI:10.1016/S0040-4020(01)80160-5

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