Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists

DOI: 10.1021/jm00073a008

Source and publish data:

Journal of Medicinal Chemistry p. 3098 - 3102 (1993)

Update date:2022-07-29

Topics:

Authors:

Houlihan

Cheon Cheon

Parrino Parrino

Handley Handley

Larson Larson

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00073a008

In an effort to determine the effect of modification of the imidazo[2,1- a]isoquinoline portion of the PAF-receptor antagonist SDZ 64-412 (1), several new analogs were prepared and evaluated in vitro and in vivo. One of these, 5-[4-[2-(3,4,5-trimethoxyphe

Full text of DOI:10.1021/jm00073a008

Products guided by the article

Product name:2-Methyl-5-{4-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-phenyl}-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Cas No:151965-16-1

R&D Labs maybe for 151965-16-1

Tianjin Te-An Chemtech Co., Ltd.(expird)

Contact:+86-22-65378638

Address:A5-8, No.80 Haiyun Street, TEDA
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou
Xi'an North Information Industry Co., Ltd. Weilv Chemical Department

Contact:+86-29-88156413

Address:Jixiang Road 99 Xi'an Shaanxi Province
Shanghai Zhihua ChemTech Co., Ltd.

Contact:+86-13774313779

Address:Room 817 Suite B 3333 Shenjiang Road
Shanghai Micro-mega Industry Co., Ltd.

Contact:0086-21-34628682;57153848

Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China

Relevant to this article

The total synthesis of the archaebacterial C40-diol and its enantiomer based on (R)-5-acetoxy-4-methylpentanoic acid

Doi:10.1007/BF00702017
(1993)
The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues

Doi:10.1002/cbic.201000641
(2011)
Design, synthesis and docking study of 5-(substituted benzylidene) thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

Doi:10.1016/j.bmcl.2014.05.099
(2014)
An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides

Doi:10.1016/j.bmcl.2014.05.075
(2014)
Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells

Doi:10.1021/ja505517t
(2014)
An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF₂CO₂Et at ambient temperature

Doi:10.1039/c4cc04591b
(2014)

Article Doi