PRACTICAL EPC SYNTHESIS OF 1,2- AND 1,3-AMINO ALCOHOLS

Article abstract of DOI:10.1016/S0040-4039(00)79340-3

An efficient synthesis of enantiomerically pure 1,2- and 1,3-amino alcohols (4,10) through the key intermediates 2 and 8a,b, obtained from L-aspartic acid, is reported.Using 4d as an example it is shown that the products can serve as percursors for unusual amino aldehydes and nonproteinogenic amino acids.