Chemoselective introduction of acetylene into hindered carbonyl group using alkynyltrifluoroborate, a solution as one step to (-)-tetrodotoxin

DOI: 10.1016/S0040-4020(01)81827-5

Source and publish data:

Tetrahedron p. 6581 - 6590 (1993)

Update date:2022-08-05

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Authors:

Yamamoto, Noboru

Isobe, Minoru

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Article abstract of DOI:10.1016/S0040-4020(01)81827-5

Optically active cyclohexane moiety precursor for tetrodotoxin molecule was synthesized by Diels-Alder cycloaddition between a bromo derivative of levoglucosenone and Danishefsky type diene. The unstable product, bromo-ketone, was converted into vinylphos

Full text of DOI:10.1016/S0040-4020(01)81827-5

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