Enzyme-catalyzed desymmetrization of meso-skipped polyols to useful chiral building blocks

Article abstract of DOI:10.1016/S0957-4166(00)80117-2

The biocatalytic desymmetrization, in presence of different enzymes, of two models of polyfunctionalized diols in a meso form was studied. PFL was found to be the most selective enzyme with excellent results in chemical and optical yield with some of the tested substrates. The obtained chiral building block was utilized for some useful synthetic transformations toward the synthesis of natural products.