Archiv der Pharmazie p. 85 - 89 (1994)
Update date:2022-07-29
Topics:
Troschutz
Dennstedt
Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.
View MoreGoldwills Pharmaceuticals Co., Ltd.
Contact:0916-2237889 13991621155
Address:North Suburb of Hanzhong city, Shaanxi Province
ShangHai Ruiyi Medical Technology Co.,Ltd.
Contact:+86-21-54718086
Address:No951 Jianchuan RD，Minhang District
ALPHA PHARMACEUTICAL CO，LTD JIANGSU
Contact:+86-527-84829968,+86-527-84829998
Address:suqian city
Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)
website:http://www.bjgreenchem.com/
Contact:+86-427-6515887
Address:301,302, 3rd Floor, Building C-7, Dongsheng Science Park, Northern Territory, Zhongguancun, No. 66, Xixiaokou Road, Haidian District, Beijing
Tianjin Jiuri New Materials Co., Ltd.
Contact:+86-22-58889220
Address:C-5/6, Vison Hill, No.1 Gonghua Road, Huayuan Hi-tech Park, Tianjin, China.
Doi:10.1007/s12039-012-0324-3
(2013)Doi:10.1039/c39920000728
(1992)Doi:10.1016/j.tet.2016.12.041
(2017)Doi:10.1055/s-0032-1317514
(2012)Doi:10.1039/C6CC08869D
(2017)Doi:10.1021/jm301311c
(2013)
