Characterization of inhibitory activities and binding mode of synthetic 6'-modified methyl N-acetyl-β-lactosaminide toward rat liver CMP-D-Neu5Ac: D-galactoside-(2->6)-α-D-sialyltransferase

DOI: 10.1016/0008-6215(93)84251-Z

Source and publish data:

Carbohydrate Research p. 179 - 194 (1993)

Update date:2022-08-03

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Authors:

Kajihara, Yasuhiro

Kodama, Hisashi

Wakabayashi, Tomio

Sato, Ken-ichi

Hashimoto, Hironobu

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Article abstract of DOI:10.1016/0008-6215(93)84251-Z

6'-Deoxy (12), 6'-thio (13), and 6'-O-tetrahydropyranosyl (14) analogues of methyl N-acetyl-β-lactosaminide (3), were synthesized from lactose.NOE experiments proved that they adopt the same conformation as that of 3.Inhibition studies using these synthet

Full text of DOI:10.1016/0008-6215(93)84251-Z

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