Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing nitrooxyalkylester moieties at the 3- and 5-positions

DOI: 10.1248/cpb.41.1049

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1049 - 1054 (1993)

Update date:2022-09-26

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Authors:

Ogawa Ogawa

Nakazato

Tsuchida

Hatayama

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Article abstract of DOI:10.1248/cpb.41.1049

We have synthesized new 1,4-dihydropyridine derivatives having nitrooxyalkylester moieties at the 3- and 5-positions in order to develop potent and long-lasting vasodilators. The antihypertensive activities of these compounds were compared with that of nifedipine. One of them, 2- nitrooxypropyl 3-nitrooxypropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro- 3,5-pyridinedicarboxylate (CD-349) was selected for further development. The structure-activity relationship is discussed.

Full text of DOI:10.1248/cpb.41.1049

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