Chemical and Pharmaceutical Bulletin p. 1049 - 1054 (1993)
Update date:2022-09-26
Topics:
Ogawa
Nakazato
Tsuchida
Hatayama
We have synthesized new 1,4-dihydropyridine derivatives having nitrooxyalkylester moieties at the 3- and 5-positions in order to develop potent and long-lasting vasodilators. The antihypertensive activities of these compounds were compared with that of nifedipine. One of them, 2- nitrooxypropyl 3-nitrooxypropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro- 3,5-pyridinedicarboxylate (CD-349) was selected for further development. The structure-activity relationship is discussed.
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Doi:10.1080/00397919308013800
(1993)Doi:10.1021/ja00263a035
(1986)Doi:10.1016/0223-5234(93)90093-T
(1993)Doi:10.1016/S0040-4039(01)95379-1
(1979)Doi:10.1016/S0022-328X(98)00596-8
(1999)Doi:10.1021/jm401138v
(2014)
