Steric acceleration of intramolecular cycloaddition reactions

Article abstract of DOI:10.1016/S0040-4020(01)88037-6

Use of conformational constraints, induced by different ortho-substituents in 1-allyloxy-2-(substituted)methylbenzenes, where the substituent is a 1,3-dipole such as the azide or 3-oxidopyridinium group, can be employed to accelerate the 1,3-dipolar cycloaddition reaction. In this manner cycloadditions that otherwise do not proceed can be forced to react.