Enzyme Assisted Synthesis of Enantiomerically Pure myo-Inositol Derivatives - Chiral Building Blocks for Inositol Polyphosphates

Article abstract of DOI:10.1016/S0957-4166(00)80058-0

Using a short and facile synthetic protocol involving highly selective, regio- and enentioselective enzymatic esterifications as key reaction steps, readily available myo-inositol is converted into optically pure 1D-1-O-butyryl-4,6-O-dibenzoyl-myo-inositol (-) - 5, a selectively protected central intermediate for the preparation of numerous inositol phosphates.