New pyridazinones: Synthesis and correlation between structure and α-blocking activity

DOI: 10.1016/0223-5234(93)90097-X

Source and publish data:

European Journal of Medicinal Chemistry p. 647 - 651 (1993)

Update date:2022-08-03

Topics:

Authors:

Corsano Corsano

Scapicchi

Strappaghetti

Marucci Marucci

Paparelli

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Article abstract of DOI:10.1016/0223-5234(93)90097-X

The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinone has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens.

Full text of DOI:10.1016/0223-5234(93)90097-X

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