New pyridazinones: Synthesis and correlation between structure and α-blocking activity

DOI: 10.1016/0223-5234(93)90097-X

Source and publish data:

European Journal of Medicinal Chemistry p. 647 - 651 (1993)

Update date:2022-08-03

Topics:

Authors:

Corsano Corsano

Scapicchi

Strappaghetti

Marucci Marucci

Paparelli

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(93)90097-X

The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinone has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens.

Full text of DOI:10.1016/0223-5234(93)90097-X

Products guided by the article

Product name:2-methyl-4-chloro-5-<4-(2-phenoxyethyl)-1-piperazinyl>-3(2H)-pyridazinone

Cas No:153276-43-8

R&D Labs maybe for 153276-43-8

Jinhua City Mingzhu Pharmaceutical Co.,Ltd.

Contact:15857995878 0579-82207761

Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
Suzhou HeChuang Chemical Co.,Ltd.

Contact:+86-512-88800520

Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
Improve Medical Technology(Nanxiong) Co., Ltd

Contact:86-751-3836997

Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
NOVASYNCS CO., LTD

Contact:0512-63006287

Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Chengdu Herbpurify Co., Ltd

website:http://www.herbpurify.com

Contact:0086-028-85249238

Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China

Relevant to this article

Enzymatic β-galactosidation of modified monosaccharides: Study of the enzyme selectivity for the acceptor and its application to the synthesis of disaccharides

Doi:10.1021/jo00083a013
(1994)
Molecular complexes of diethyl N, N ′-1,3-phenyldioxalamate and resorcinols: Conformational switching through intramolecular three-centered hydrogen-bonding

Doi:10.1021/cg401500k
(2014)
Free Radical Reactions of N-Heterocyclic Compounds. XI. Reaction of 3-Methyl-pyrazolin-5-ones with Phenoxy Radicals

Doi:10.1002/prac.19933350706
(1993)
Iminopropadienones, RN=C=C=C=O : Theory and Experiment

Doi:10.1021/j100055a007
(1994)
Dynamic covalent side-chain cross-links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers

Doi:10.1002/psc.2596
(2014)
Synthesis and biological activity of the neuronal calcium channel blocker 2-amino-1-(2,5-dimethoxyphenyl)-5-trifluoromethyl benzimidazole (NS-649)

Doi:10.1016/0960-894X(96)00010-8
(1996)

Article Doi