A novel and highly efficient desymmetrization of a meso-anhydride by a chiral Grignard reagent

DOI: 10.1016/S0040-4039(00)61451-X

Source and publish data:

Tetrahedron Letters p. 8063 - 8066 (1993)

Update date:2022-07-29

Topics:

Authors:

Real Real

Kronenthal

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Article abstract of DOI:10.1016/S0040-4039(00)61451-X

The addition of the chiral oxazolidine Grignard 3c to anhydride 1, followed by in situ NaBH₄ reduction and acid hydrolysis, provides aldehyde 2 in greater than 98% enantiomeric excess.

Full text of DOI:10.1016/S0040-4039(00)61451-X

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