
Tetrahedron Letters p. 6811 - 6814 (1998)
Update date:2022-09-26
Topics:
Rychnovsky, Scott D.
Sinz, Christopher J.
Lewis acids promote the coupling of 4-acetoxy-1,3-dioxanes 1 with crotyl-metal species to generate propionate motifs such as 2. The reactions show a marked dependence on Lewis acid, the crotyl metal species, and the presence and stereochemical disposition of a C5 methyl group. A 1,3-syn methyl relationship is favored in these additions.
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