Tetrahedron Letters p. 7489 - 7492 (1993)
Update date:2022-08-03
Topics:
Baldwin, Jack E.
Field, Robert A.
Lawrence, Christopher C.
Merritt, Kirsten D.
Schofield, Christopher J.
The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus P8648 has been investigated using (2S, 4S)[4-2H1]-proline and (2S, 4R)-[4-2H1]-proline and found to occur with retention of stereochemistry at C-4 of proline.
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Doi:10.1039/c1nj20539k
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