Stereocontrolled synthesis of cyclic ethers by intramolecular hetero-Michael addition. 3. Enantiomeric synthesis of highly functionalized and fused tetrahydropyrans

Article abstract of DOI:10.1016/S0040-4039(00)73936-0

A methodology based on intramolecular hetero-Michael addition of properly functionalized alkoxy-γ-benzoyloxy-α,β-unsaturated esters for the synthesis of highly substituted and fused poly-tetrahydropyran nuclei of marine polyether toxins with absolute control of all the stereocentres is described.