Synthesis and antimicrobial evaluation of novel oxa(thia)diazolylquinolines and oxa(thia)diazepino[7,6-b] quinolines

Article abstract of DOI:10.1002/ardp.19933260812

Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3[(substituted)thiocarbamoyl-hydrazonomethyl]-2-chloroquinolines and 3-aroylhydrazonomethyl-2-chloroquinolines: 3-(3-Acetyl-5-(substituted)-2,3-dihydro-1,3,4-oxa(thia)diazol-2-yl)-2- chloroquinolines(4; 5), 3-(5-(substituted)-1,3,4-oxa(thia)diazol-2-yl)-2-chloroquinolines (6; 7), and 2-(substituted)-1,3,4-oxa(thia)diazepino[7,6-b]quinolines (8; 9). The antimicrobial activity of these compounds was studied.