Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B

DOI: 10.1016/0223-5234(93)90046-H

Source and publish data:

European Journal of Medicinal Chemistry p. 917 - 926 (1993)

Update date:2022-07-30

Topics: Inhibitors Analog Papain Cathepsin B

Authors:

Giordano

Calabretta

Gallina Gallina

Consalvi

Scandurra

Chiaia Noya

Franchini

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Article abstract of DOI:10.1016/0223-5234(93)90046-H

Eight new analogs of L-trans-epoxysuccinyl-L-leucylamido(3-methyl)butane (E-64-c) containing Phe, Tyr, Tyr(I) or Tyr(I₂) in place of Leu, were synthesized and tested as inhibitors of papain, bovine spleen cathepsin B, calpain I and II from porc

Full text of DOI:10.1016/0223-5234(93)90046-H

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