Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B

Article abstract of DOI:10.1016/0223-5234(93)90046-H

Eight new analogs of L-trans-epoxysuccinyl-L-leucylamido(3-methyl)butane (E-64-c) containing Phe, Tyr, Tyr(I) or Tyr(I₂) in place of Leu, were synthesized and tested as inhibitors of papain, bovine spleen cathepsin B, calpain I and II from porc