Thioacylating Agents. Use of Thiobenzimidazolone Derivatives for the Preparation of Thiotuftsin Analogs.

Article abstract of DOI:10.1016/S0040-4020(01)81544-1

The properties and characteristic reactions of thioacylating reagents 1 are described.These reagents are able to introduce thioamide linkages into a growing peptide at a specific site in the sequence.The generality and efficiency of this methodology is demonstrated by the synthesis of the three monothioanalogues of tuftsin.