Synthesis and pharmacological study of new calcium antagonists analogues of cinnarizine and flunarizine

Article abstract of DOI:10.1016/0223-5234(93)90049-K

Several phosphonic diethyl esters were synthesized and their calcium antagonistic activity evaluated in vitro.The diethyl phosphonate group was condensed on substituted , <(2-benzofuranyl)phenylmethyl>, <(4-(diphenylmehyl-1-piperazinyl) methyl>, <4-(4-diphenylmethyl-1-piperazinyl methyl) phenylmethyl>, and <4-(3-phenyl-2-propenyl)-1-piperazinyl methyl> groups.Despite the presence of the diethyl phosphonate moiety and the benzhydrylpiperazinyl group, both present in potent calcium antagonist structures, only 1 of the 19 synthesis compounds exhibited a calcium antagonistic profile. diethyl phosphonate / benzhydryl piperazine / calcium antagonist