Tetrahedron Letters p. 7269 - 7272 (1990)
Update date:2022-09-26
Topics:
Vu, Huynh
McCollum, Christie
Jacobson, Karen
Theisen, Pete
Vinayak, Ravi
et al.
A new set of base protecting groups for cyanoethylphosphoramidite nucleosides has been developed which decreases the post-synthesis time requirements.The traditional purine amide protecting groups, which require 8 - 16 hours at 55 deg C for deprotection in ammonia, have been replaced with the dimethylformamidine group.Oligonucleotides made with the new reagents require only 1 hour at 55 deg C or 8 hours at room temperature for complete deprotection.Dialkylformamidine phosphoramidites exhibit enhanced resistance to depurination compared to the traditional, or even the phenoxyacetyl, phosphoramidites.
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