Azoalkene route to methyl 2,5-dimethyl-4[2-(phenylmethyl)benzoyl]-1H- pyrrole-3-carboxylate (FPL 64176) and analogues: Synthesis of 1-(BOC- amino)pyrrole-3-carboxylates and their conversion to 1H-pyrroles via 1- aminopyrroles

Article abstract of DOI:10.1055/s-1994-25440

A new route to the calcium channel activator methyl 2,5-dimethyl-4[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues is presented. Reaction of activated diones with BOC-azoalkenes gave pyrroles with the required functionality bu