Stereoselective synthesis of dimethoxy[n.2]metacyclophanes

Article abstract of DOI:10.1246/bcsj.66.3828

Dimethoxy[n.2]metacyclophanes were obtained in 5 45% yields through [2+2] photocycloaddition of corresponding styrene derivatives. These cyclobutane- fused metacyclophanes were assigned to be of only syn conformation (n = 6, 8, 10, and 12). The cyclobutane ring exclusively tool the opposite direction to the alkyl bridged chain.