Tetrahedron p. 171 - 188 (1994)
Update date:2022-08-03
Topics:
Goument, Bertrand
Duhamel, Lucette
Mauge, Robert
We describe one synthesis of (S)-fenfluramine and several syntheses of its precursors (R)- and (S)-1-(meta-trifluoromethylphenyl)propan-2-ols.They were obtained from the asymmetric epoxidation of the primary allylic alcohol 5 and from the kinetic resolution with asymmetric epoxidation of teh secondary allylic alcohol 6.
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