Asymmetric syntheses of (S)-Fenfluramine using Sharpless Epoxidation Methods

Article abstract of DOI:10.1016/S0040-4020(01)80743-2

We describe one synthesis of (S)-fenfluramine and several syntheses of its precursors (R)- and (S)-1-(meta-trifluoromethylphenyl)propan-2-ols.They were obtained from the asymmetric epoxidation of the primary allylic alcohol 5 and from the kinetic resolution with asymmetric epoxidation of teh secondary allylic alcohol 6.