U. Sirion et al. / Tetrahedron Letters 48 (2007) 3953–3957
3957
In conclusion, the CuI-catalyzed, 1,3-dipolar cycloaddi-
tion reaction was applied successfully to the synthesis of
small, F-18-labeled, biomolecule-like compounds, and
an optimal reaction condition was developed for one-
pot, two-step reaction without interim purification. This
condition was employed in various 1,2,3-triazole synthe-
ses of F-18-labeled azides or acetylenes and their corre-
sponding azide or acetylene compounds, including
biomolecules. We expect that the reaction condition pre-
sented here will widen the application of the click reac-
tion for the preparation of F-18-labeled peptides to
various types of biomolecules.
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Acknowledgments
This work was supported by the National Research and
Development Program of MOST, Korea (2005-03184).
Supplementary data
Experimental procedures and spectral data for all com-
pounds are given in the Supplementary data. Supple-
mentary data associated with this article can be found,
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