Tetrahedron Letters p. 3953 - 3957 (2007)
Update date:2022-08-02
Topics:
Sirion, Uthaiwan
Kim, Hee Jun
Lee, Jae Hak
Seo, Jai Woong
Lee, Byoung Se
Lee, Sang Ju
Oh, Seung Jun
Chi, Dae Yoon
The Cu(I)-catalyzed, 1,3-dipolar cycloaddition reaction was applied successfully to the synthesis of small, F-18-labeled biomolecules, and an optimal condition was developed for one-pot, two-step reaction without any interim purifications. This technique was employed in various F-18-labeled, 1,2,3-triazole syntheses with high radiochemical yield.
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