A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts

Article abstract of DOI:10.1111/j.2042-7158.1994.tb03751.x

W84 (N,N,N',N'-tetramethyl-N,N'-bis-(3-phthalimidopropyl)-N,N'-hexane-1,6-diyl-bis -ammonium dibromide) is a potent stabilizer of antagonist binding to muscarinic receptors; however, W84 hydrolyses in aqueous buffered medium. The synthesis of the stable d