Improved synthesis of biotinol-5′-AMP: Implications for antibacterial discovery

DOI: 10.1021/ml500475n

Source and publish data:

ACS Medicinal Chemistry Letters p. 216 - 220 (2015)

Update date:2022-07-29

Topics:

Authors:

Tieu, William

Polyak, Steven W.

Paparella, Ashleigh S.

Yap, Min Y.

Soares Da Costa, Tatiana P.

Ng, Belinda

Wang, Geqing

Lumb, Richard

Bell, Jan M.

Turnidge, John D.

Wilce, Matthew C. J.

Booker, Grant W.

Abell, Andrew D.

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Article abstract of DOI:10.1021/ml500475n

An improved synthesis of biotinol-5′-AMP, an acyl-AMP mimic of the natural reaction intermediate of biotin protein ligase (BPL), is reported. This compound was shown to be a pan inhibitor of BPLs from a series of clinically important bacteria, particularl

Full text of DOI:10.1021/ml500475n

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