Direct Amino-Crotylsilylation of Achiral Acetals and Aldehydes: Asymmetric Synthesis of Homoallylic Amines and Functionalized Pyrrolidines

DOI: 10.1021/jo00089a004

Source and publish data:

Journal of Organic Chemistry p. 2674 - 2675 (1994)

Update date:2022-08-04

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Authors:

Panek, James S.

Jain, Nareshkumar F.

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Article abstract of DOI:10.1021/jo00089a004

The condensation between chiral (E)-crotylsilanes 1 and in situ-generated achiral N-acylimines produces homoallylic N-acylamines 3 or tetrasubstituted N-acylpyrrolidines 4 with high levels of diastereoselection.

Full text of DOI:10.1021/jo00089a004

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