A new synthetic route to macrocycles: Synthesis of large ring enaminolactones

DOI: 10.1016/S0040-4039(00)76754-2

Source and publish data:

Tetrahedron Letters p. 1545 - 1548 (1994)

Update date:2022-07-29

Topics:

Authors:

Jourdain

Pommelet

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Article abstract of DOI:10.1016/S0040-4039(00)76754-2

Macrocyclic enaminolactones 5 are prepared in three steps from commercially available chloroalcohols 1. The cyclization step is performed by intramolecular nucleophilic addition of the hydroxy group to an aminomethyleneketene generated by thermolysis.

Full text of DOI:10.1016/S0040-4039(00)76754-2

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