Bioorganic and Medicinal Chemistry Letters p. 1607 - 1612 (1999)
Update date:2022-08-04
Topics:
Jordan, Douglas B.
Lessen, Thomas A.
Wawrzak, Zdzislaw
Bisaha, John J.
Gehret, Troy C.
Hansen, Stephen L.
Schwartz, Rand S.
Basarab, Gregory S.
Insights gained from a crystal structure of scytalone dehydratase led to the design of carboxamide inhibitors with a phenoxypropyl group substituted on the nitrogen atom. Potent enzyme inhibitors were synthesized around this motif, the best of which provided excellent control of rice blast disease in greenhouse assays and outdoor field trials.
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