Antipsoriatic Anthrones with Modulated Redox Properties. 2. Novel Derivatives of Chrysarobin and Isochrysarobin - Antiproliferative Activity and 5-Lipoxygenase Inhibition

DOI: 10.1021/jm00037a017

Source and publish data:

Journal of Medicinal Chemistry p. 1660 - 1669 (1994)

Update date:2022-08-04

Topics:

Authors:

Mueller, Klaus

Leukel, Peter

Ziereis, Klaus

Gawlik, Ingo

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Article abstract of DOI:10.1021/jm00037a017

A novel series of 2- and 3- substituted 1,8-dihydroxy-9(10H)-anthracenones were synthesized and tested for their inhibitory activity against 5-lipoxygenase (5-LO) in bovine polymorphonuclear leukocytes and the growth of human keratinocytes.Structure-activ

Full text of DOI:10.1021/jm00037a017

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