An efficient and enantioselective synthesis of a chiral primary amine

Article abstract of DOI:10.1016/S0040-4039(00)73087-5

An efficient and enantioselective method for the preparation of a chiral primary amine has been developed. Starting from N-protected L or D-amino acid the sequence involves coupling with N-methoxy-N-methylamine, acylation, olefination with potassium bis(trimethylsilyl)amide, and hydrogenation.