Studies on β-lactam antibiotics - Iv: An improved synthesis of 3-(isothiazolylthiomethyl)cephalosporins and its application to new derivatives

Article abstract of DOI:10.7164/antibiotics.47.477

An improved synthesis and in vitro activity of cephalosporins with a (4-carboxy-3-hydroxy-5-isothiazolyl)thiomethyl group at the 3-position and its application to the preparation of new derivatives are described. These compounds showed excellent activity