Selective dopamine D-2 autoreceptor agonists with 8-azaindole substructure: Synthesis and theoretical investigations

Article abstract of DOI:10.1002/ardp.19943270706

Starting from the 1,3-dipolar cycloaddition product 6a the peri-fused β-ketoester 7 is prepared. 7 is employed as a key intermediate for the synthesis of the D-2 autoreceptor agonist 5. Two alternative approaches are used for installing the amino function