Synthetic studies on aphidicolane and stemodane diterpenes. V. A facile formal total synthesis of (±)-aphidicolin via a Lewis acid-mediated stereoselective spiroannelation

DOI: 10.1248/cpb.43.1407

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1407 - 1411 (1995)

Update date:2022-07-29

Topics:

Authors:

Tanaka Tanaka

Okuda Okuda

Murakami

Yoshino Yoshino

Mikamiyama

Kanda Kanda

Kim - Kim -

Iwata Iwata

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Article abstract of DOI:10.1248/cpb.43.1407

Formal total synthesis of (±)-aphidicolin (1) was achieved via a Lewis acid-mediated stereoselective spiroannelation reaction as a key step. The bisbenzyl acetal (2) was synthesized from the readily available dimethyl acetal (4). Treatment of 2 with trime

Full text of DOI:10.1248/cpb.43.1407

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