Synthetic studies on aphidicolane and stemodane diterpenes. V. A facile formal total synthesis of (±)-aphidicolin via a Lewis acid-mediated stereoselective spiroannelation

DOI: 10.1248/cpb.43.1407

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1407 - 1411 (1995)

Update date:2022-07-29

Topics:

Authors:

Tanaka Tanaka

Okuda Okuda

Murakami

Yoshino Yoshino

Mikamiyama

Kanda Kanda

Kim - Kim -

Iwata Iwata

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.1407

Formal total synthesis of (±)-aphidicolin (1) was achieved via a Lewis acid-mediated stereoselective spiroannelation reaction as a key step. The bisbenzyl acetal (2) was synthesized from the readily available dimethyl acetal (4). Treatment of 2 with trime

Full text of DOI:10.1248/cpb.43.1407

NII-Electronic Library Service

Products guided by the article

Product name:4-bromobutanal dibenzyl acetal

Cas No:157491-70-8

R&D Labs maybe for 157491-70-8

Chiral Quest (Suzhou) Company Ltd

website:http://www.chiralquest.com

Contact:+86-0512-62956066

Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park
Jiangsu Taihu New Materials Holding Co., Ltd

Contact:+86-519-86160108

Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
Xi'an Herbland Tech Inc.

Contact:+86-29-88710656

Address:South Tai bai Road, High Tech Development Zone, Xi'an China
Hebei Tete Trade Co., Ltd.

Contact:86-311-83160559

Address:shijiazhuang
ZiBO KuoDing Trade company Ltd

website:http://www.sdzbkd.com

Contact:86-13361591822

Address:GongQingTuan road

Relevant to this article

Asymmetric Synthesis of (2S,3R)-Amino-2-Hydroxydecanoic Acid: The Unknown Amino Acid Component of Microginin

Doi:10.1016/S0957-4166(00)86173-X
(1994)
Hydroarylation of arynes catalyzed by silver for biaryl synthesis

Doi:10.1021/ja500292x
(2014)
Palladium-catalyzed synthesis of benzofurans via C-H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine

Doi:10.1039/c3cc49717h
(2014)
The synthesis and strecker reaction of 2-chlorotetrafluoroethanesulfinyl ketimines

Doi:10.1021/jo500008e
(2014)
Functionalized bis(1-methylimidazol-2-yl)methane and 1-(1-methylimidazol-2- yl)methyl-3,5-dimethylpyrazole and their reactions

Doi:10.1016/j.jorganchem.2014.01.021
(2014)
Asymmetric synthesis of P -stereogenic diarylphosphinites by palladium-catalyzed enantioselective addition of diarylphosphines to benzoquinones

Doi:10.1021/ja501007t
(2014)

Article Doi