Tetrahedron Asymmetry p. 1131 - 1134 (1994)
Update date:2022-08-03
Topics: Synthesis Optical purity
Fedij, Victor
Lenoir, Edward A.
Suto, Mark J.
Zeller, James R.
Wemple, James
Methylcerium dichloride has been found to undergo bis addition to nitriles to produce tertiary carbinamines with retention of optical purity at the ? position.This result is used in the development of a short, economical synthesis of the 1,8-naphthyridine antiinfective agent, PD 138312.
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