An Efficient Method for the Synthesis of (R)-3-(1-Amino-1-methylethyl)pyrrolidines for the Antiinfective Agent, PD 138312

DOI: 10.1016/0957-4166(94)80138-X

Source and publish data:

Tetrahedron Asymmetry p. 1131 - 1134 (1994)

Update date:2022-08-03

Topics: Synthesis Optical purity

Authors:

Fedij, Victor

Lenoir, Edward A.

Suto, Mark J.

Zeller, James R.

Wemple, James

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0957-4166(94)80138-X

Methylcerium dichloride has been found to undergo bis addition to nitriles to produce tertiary carbinamines with retention of optical purity at the ? position.This result is used in the development of a short, economical synthesis of the 1,8-naphthyridine antiinfective agent, PD 138312.

Full text of DOI:10.1016/0957-4166(94)80138-X

Products guided by the article

Product name:(R)-3-(1-amino-1-methylethyl)-1-benzylpyrrolidine

Cas No:157528-57-9

R&D Labs maybe for 157528-57-9

Dalian Join King Biochemical Tech. Co., Ltd.

Contact:0411 39216206

Address:814 First State Blvd
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Huayi Isotopes Co.

Contact:+ 86 512 52491118

Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
TIANJIN NORTH JINHENG CHEMICAL PLANT.

Contact:0086-22-59952083

Address:DongShigu Country In JiXian TianJin China
LINAN HAIHUA CHEMICAL CO LTD

Contact:86-571-61063068

Address:LINAN

Relevant to this article

Ketene reactions with tertiary amines

Doi:10.1021/jo402438w
(2014)
Rhodium-catalyzed homogeneous reductive amidation of aldehydes

Doi:10.1002/adsc.201200837
(2013)
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy

Doi:10.1016/j.bmcl.2018.05.014
(2018)
Hesparalin, a new natural choline ester in the seed of Hesperis matronalis L

Doi:10.1002/ardp.19673000214
(1967)
Synthesis, conformational assignment, and anti-inflammatory activities of N-arylidene-2-(4-chloro-2-(2-substituted phenoxy)phenyl)acetic acid hydrazides

Doi:10.1007/s00044-016-1656-1
(2016)
Synthesis and antibacterial evaluation of 3-Farnesyl-2-hydroxybenzoic acid from Piper multiplinervium

Doi:10.1016/j.fitote.2014.01.005
(2014)

Article Doi