Diastereoselective Synthesis of γ-Hydroxy-β-amino Alcohols, (2S,3S)- and (2S,3R)-Threoninol and -Hydroxyphenylalaninol, from (R)-Glycidol via the Derived 4-Hydroxymethyloxazolidinone

Article abstract of DOI:10.1016/S0957-4166(00)86162-5

Syntheses of enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and (2S,3R)-hydroxyphenylalaninol are demonstrated starting from (R)-glycidol via (S)-4-methoxycarbonyl-2-oxazolidinone by monoalkylation of the ester followed by diastereoselective reduct