Preparation of 17-amino-22-(4'-azido-3'-125iodophenacyl)-17- demethoxygeldanamycin (1): An ansamycin for photoaffinity labeling

Article abstract of DOI:10.1002/jlcr.2580340606

An azido-¹²⁵iodo-ansamycin (1) in the geldanamycin family was prepared in two steps in one reacton vessel from 17-amino-22-(4'-aminophenacyl)-17- demethoxygeldanamycin (3). The title compound was suitable for photoaffinity labeling proteins tha