Journal of Pharmaceutical Sciences p. 1269 - 1273 (1994)
Update date:2022-07-30
Topics:
Iyer
Boal
Phillips
Thakker
Egan
The synthesis and anti-HIV activity of selected (acyloxy)-alkyl esters of trisodium phosphonoformate (foscarnet sodium) are described. The conversion of bis(trimethylsilyl) (alkoxycarbonyl)phosphonates 11a-d to the corresponding disilver salts 12a-d and their subsequent reaction with iodoalkyl acrylates 4a-c gave the desired bis(acyloxyalkyl) phosphonates 6- 9(a-c). Of the analogs tested, only the dichlorophenyl analog 9a showed a dose-dependent inhibition of HIV activity in H9 cells. Using 31P-NMR, bioreversibility has been investigated in an attempt to rationalize these results.
View MoreHangzhou yi lu biont technology Co., LTD
Contact:+86-571-88152630
Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
Contact:86-25-51817806
Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
Hangzhou Ocean Chemical Co., Ltd.
website:http://www.hzoceanchem.com
Contact:+86-571-88025872, 28272092, 28272096
Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China
Shandong Dayi Chemical Co., Ltd.
website:http://www.dayi.com.cn
Contact:+86- 535-7388728. 15306386031
Address:No 1 Danya west road, Laiyang City, Shandong province
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.
Contact:15857995878 0579-82207761
Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
Doi:10.1016/j.saa.2014.01.083
(2014)Doi:10.1016/0040-4039(94)85043-7
(1994)Doi:10.1021/jo00101a062
(1994)Doi:10.1002/hlca.19940770425
(1994)Doi:10.1021/jo00106a026
(1995)Doi:10.1016/j.poly.2017.04.014
(2017)
