Enhancement of mutagenic activity of 9-aminoacridine by introducing a nitro group into the molecule.

Article abstract of DOI:10.1271/bbb.58.1420

Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.

Full text of DOI:10.1271/bbb.58.1420

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Enhancement of Mutagenic Activity of 9-
Aminoacridine by Introducing a Nitro Group into the
Molecule
Hideyuki Tomosakaa, Saburo Omataab & Kentaro Anzaiac
a Department of Bio system Science, Graduate School of Science and Technology, Niigata
University Igarashi, Niigata, Niigata 950–21, Japan
b Department of Biochemistry, Faculty of Science, Niigata University, Igarashi, Niigata,
Niigata 950–21, Japan
c Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka,
Shinjuku-ku, Tokyo 162, Japan
Published online: 12 Jun 2014.
To cite this article: Hideyuki Tomosaka, Saburo Omata & Kentaro Anzai (1994) Enhancement of Mutagenic Activity of
9-Aminoacridine by Introducing a Nitro Group into the Molecule, Bioscience, Biotechnology, and Biochemistry, 58:8,
1420-1423, DOI: 10.1271/bbb.58.1420
To link to this article: http://dx.doi.org/10.1271/bbb.58.1420
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