Synthesis of a potential antiviral compound: 5-Bromoethynyl-2'- deoxyuridine

Article abstract of DOI:10.1016/S0040-4020(01)85560-5

5-Bromoethynyluracil and its deoxyriboside can be prepared in good yields starting from dibromovinyluracil, which is accesible by literature methods. 5-Bromoethynyl-deoxyuridine is less effective against HSV-1 than E- (bromovinyl)-deoxyuridine but, similar to BVDU, seems to exhibit a certain selectivity toward HSV-1. Molecular calculations prove the spatial similarity of both compounds.