Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus

Article abstract of DOI:10.1021/jm00049a013

The ability of quisqualic acid (1) to sensitize neurons to depolarization by ω-phosphono α-amino acid analogues of excitatory amino acids is a highly specific phenomenon and is termed the QUIS effect. In an attempt to elucidate the structure-activity rela