Total Synthesis of the Ethanol Inducible, Proinflammatory Autacoid 3(S)-Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues

DOI: 10.1016/S0040-4039(00)73170-4

Source and publish data:

Tetrahedron Letters p. 1825 - 1828 (1994)

Update date:2022-07-29

Topics:

Authors:

Chauhan, Kamlesh

Bhatt, Rama K.

Falck, J. R.

Capdevila, Jorge H.

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Article abstract of DOI:10.1016/S0040-4039(00)73170-4

3(S)-Hydroxy-Leukotriene B4 (1a), its 3(R)-epimer 1b, and 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral β-hydroxylactones 7/9. - Key Words: eicosanoid, chelati

Full text of DOI:10.1016/S0040-4039(00)73170-4

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