Synthesis of the optical isomers of 4-[1-(4-tert-butylphenyl)-2- oxopyrrolidine-4-yl]methyloxybenzoic acid (S-2) and their biological evaluation as antilipidemic agent

DOI: 10.1248/cpb.47.1549

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1549 - 1554 (1999)

Update date:2022-07-29

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Authors:

Ohno, Tomoyasu

Yano, Shin-Go

Yamada, Haruo

Shirasaka, Tetsuhiko

Yamamoto, Akira

Kobayashi, Kimiko

Ogawa, Kazuo

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Article abstract of DOI:10.1248/cpb.47.1549

The enantiomers of (±)-4-[1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4- yl]methyloxybenzoic acid (S-2), a new antilipidemic agent having dual action on the plasma triglyceride (TG) and cholesterol (Cho) lowering effects, were prepared via separation by Chir

Full text of DOI:10.1248/cpb.47.1549

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Product name:(S)-N-[α-methyl(4-methyl)benzyl]-(R)-[1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4-yl]carboxamide

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