Journal of Medicinal Chemistry p. 4570 - 4578 (1995)
Update date:2022-09-26
Topics:
Li
Anderson
Burton
Cogburn
Collins
Garland
Gregory
Huang
Isakson
Koboldt
Logusch
Norton
Perkins
Reinhard
Seibert
Veenhuizen
Zhang
Reitz
A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors. The methyl sulfone analogs 7 showed excellent COX-2 activity, with IC50s ranging from
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Doi:10.1055/s-0036-1590951
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(1994)
