1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents

DOI: 10.1021/jm00022a023

Source and publish data:

Journal of Medicinal Chemistry p. 4570 - 4578 (1995)

Update date:2022-09-26

Topics:

Authors:

Anderson

Burton Burton

Cogburn Cogburn

Collins Collins

Garland Garland

Gregory Gregory

Huang Huang

Isakson Isakson

Koboldt Koboldt

Logusch Logusch

Norton Norton

Perkins Perkins

Reinhard

Seibert Seibert

Veenhuizen

Zhang Zhang

Reitz Reitz

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Article abstract of DOI:10.1021/jm00022a023

A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors. The methyl sulfone analogs 7 showed excellent COX-2 activity, with IC₅₀s ranging from

Full text of DOI:10.1021/jm00022a023

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